5C-AKB48
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5C-AKB48

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5C-AKB48 is an indazole-based synthetic cannabinoid that has been sold online as a designer drug.Structurally it closely resembles compounds from patent WO 2003/035005 but with a 5-fluoropentyl chain on the indazole 1-position.
5C-AKB48 is a more potent form of AKB-48, which acts upon the cannabinoid receptors, and is a key component of many synthetic cannabis blends. 5C-AKB48 is suitable for comparable study into the effects of banned agonists upon the CB2 receptors. BAC offers 5C-AKB48 for the purposes of research only. It not for recreational use or human consumption. BE SAFE
Formal Name N-((3s,5s,7s)-adamantan-1-yl)-1-(5-chloropentyl)-1H-indazole-3-carboxamide
Chemical FormulaC23H30ClN3O
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Product Description

5C-AKB48 Cannabinoids are naturally occurring compounds found in the Cannabis sativa plant. Of over 480 different compounds present in the plant, only around 66 are termed cannabinoids.

The most well known among these compounds is the delta-9-tetrahydrocannabinol (Δ9-THC), which is the main psychoactive ingredient in cannabis.

Cannabidiol (CBD) is another important component, which makes up about 40% of the plant resin extract.

Purpose
The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available.

Methods
An in-house smoking device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity.

Results
For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent.

Conclusions
This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

Cannabinoids are naturally occurring compounds found in the Cannabis sativa plant. Of over 480 different compounds present in the plant, only around 66 are termed cannabinoids.

The most well known among these compounds is the delta-9-tetrahydrocannabinol (Δ9-THC), which is the main psychoactive ingredient in cannabis.

Cannabidiol (CBD) is another important component, which makes up about 40% of the plant resin extract.

Classes of cannabinoids 5C-AKB48

The cannabinoids are separated into the following subclasses:

  • Cannabigerols (CBG)
  • Cannabichromenes (CBC)
  • Cannabidiol (CBD)
  • Tetrahydrocannabinol (THC)
  • Cannabinol (CBN)
  • Cannabinodiol (CBDL)
  • Other cannabinoids including cannabicyclol (CBL), cannabielsoin (CBE) and cannabitriol (CBT)

Differences between cannabinoids

Cannabinoids exert their effects by interacting with specific cannabinoid receptors present on the surface of cells.

These receptors are found in different parts of the central nervous system and the two main types of cannabinoid receptors in the body are CB1 and CB2.

In 1992, a naturally occurring substance in the brain that binds to CB1 was discovered, called anandamide. This cannabinoid-like chemical and others that were later discovered are referred to as endocannabinoids.

The effects of cannabinoids depends on the brain area involved. Effects on the limbic system may alter the memory, cognition and psychomotor performance; effects on the mesolimbic pathway may affect the reward and pleasure responses and pain perception may also be altered

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